IMM250H1 Chapter Notes - Chapter 1: Lymphocyte, Cell-Mediated Immunity, Clonal Selection
Document Summary
Black death: bites from rodent fleas/handling infected rodent. People who recovered from illness better at treating sick people. It was eventually gone because: no animal reservoir, only contagious at symptomatic stage so it was easily watched, everyone worldwide was concerned, vaccine was easily administered e) there was enough funding. Inoculated 8 year old with cowpox blisters and then disease. Germ theory of disease: pathogens cause disease, developed ways for cultivating pure cultures of bacteria (anthrax & tb) Vaccines: used spoiled cholera to induce acquired immunity in chickens. Cellular immunity phagocytes protect us from infection: a rose thorn in starfish larvae is engulfed by phagocytosis by white blood cells. Humoral immunity serum (non-cellular) containing anti-toxins from guinea pigs with diphtheria gave protection from disease. Side chain theory: antitoxins are receptors that match up to toxins. Wrong: cells have diff. antitoxins, selected by diff. antigens. (multiple antibodies)
