IMM250H1 Chapter Notes - Chapter 5: Endothelium, Immunoglobulin A, Bone Marrow
Document Summary
Priming: naive lymphocyte activated: antigen binding, cell to cell contact, cytokines. Na ve cells: lymphocytes that haven"t been activated by antigen. Effector cells: short-lived cells that kill (b: plasma cells & t: th effectors, ctls) Memory cells: long-lived cells in resting state, readily re-activated by antigen encounter (b: memory b cells & t: memory th & tc) Diversity comes from bcr and tcr genes. Where lymphocytes gather and meet antigens to talk with other cells. Diffuse follicles patches organ: primary lymphoid tissues: where lymphocytes mature. Central tolerance is made (not allergic to self: bone marrow where b cells mature, thymus where t cells mature, secondary: where they are activated. Lymph nodes: filters antigen in tissues: spleen: filters antigens in blood, malt (mucosa related tissue) Balt bronchi (lower resp. : salt (skin related) Post capillary venules: where blood flow changes from arteries to veins. High endothelial venules (hevs): lined w/ endothelial cells with cuboidal/high shape.
