07 TCR complext

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Victor Barac

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TCR Complex Signal Transduction When a T cell meets an antigen presenting cell... – You need lots of TCRs engaging MHCs to get a signal   need SMAC composed of...  TCRs and co-receptors to clustered on one side of the cell stimulated by antigen recognition  Integrins surrounding the TCR + co-receptor zone o They bind the APC complement integrins to seal the two cells together – Stages of T cell activation:  Membrane events: seconds  Cytoplasmic events: minutes  Novel gene transcription: hours Immunoreceptor Tyrosine Activation Motif (ITAM) – Present on cytoplasmic tail of many cell surface receptors that pass signals – 2 tyrosines (Y) separated by 9 – 12 aas  Y X X [L/V] X6–9 Y X X [L/V]  X = any aa, L = leucine, V = valine – Phosphorylated by Src family kinases  Ex// Lck, Blk, Fyn, Lyn – Recognized by another kinase family with SH2 (Src homology 2) domains 1. Resting T cell  ITAMs not phos.  Fyn bound to cytoplasm
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