PCL200H1 Chapter Notes - Chapter 8: Cannabis Sativa, Cannabinoid Receptor Type 1, Gpr55
Document Summary
Cannabis is not one drug, but a collection of drugs that are contained in the leaf of the plant cannabis sativa. The two components that have effects on the brain are delta-9- tetrahydrocannabinol (thc) and cannabidiol (cbd) Thc and an analog of thc called nabiline are approved for the treatment of nausea and vomiting caused by chemotherapy, and to increase appetite in patients with aids. It is used off-label for many conditions, including neuropathic pain and anorexia. Benefits: increased appetite, reduced nausea, and bain relief. Thc is also responsible for the high associated with cannabis. Impairs cognition and memory, causes psychomotor retardation which can impair driving. At larger doses, thc can cause anxiety and paranoia, and exacerbate symptoms of schizophrenia. Can also increase the risk of developing schizophrenia when consumed by people younger than 25. Central nervous system effects: psychological, perception, sedative, cognition, motor function, analgesic (similar in efficacy to codeine), anti-emetic (reduces vomiting), tolerance, dependence.
