PCL102H1 Chapter n/a: PCL102H1 Chapter n/: PCL102H1 Chapter n/: PCL102H1 Chapter : PCL102H1 Chapter : Biopharmaceutical Research & Development (READING)
16 Jan 2019
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Document Summary
New medicines fewer side effects, fewer hospitalizations, improved quality of life, increased productivity & extended lives. Advances in molecular medicine and powerful tools to enhance computational capacity are enabling researchers to better understand the inner workings of human disease at the molecular level. Discovery process identify an investigational drug and perform initial tests in the lab. Personalized medicine (aka precision medicine) safety and efficacy is greatly depending on the patient"s molecular profile and genetic makeup. Get the right treatment to the right patient at the right dose for the first time through molecular diagnostic tests and targeted therapies. Issue: because it is personalized, the patient population is narrower and patient recruitment is more difficult; clinical trial protocols must be modified and enhanced. Choose a molecule to target with a drug ( target validation ) conduct studies in cells, tissues and animal models to determine whether the target can be influence by a medicine.
