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PSL301H1 (21)
Chapter

BLOOD CLOTTHING (LEC 5).docx

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Department
Physiology
Course
PSL301H1
Professor
Shaun Burns
Semester
Winter

Description
BLOOD CLOTTHING (557-564) • Hemostasis o Process of keeping blood within damaged vessel • Vasoconstriction • Decreases blood flow and pressure to wounded area • Temporary platelet plug • Plug formed via platelet adhesion o Stick to exposed collagen in damaged area o Adhered platelets activate, release cytokines o Reinforce local vasoconstriction, recruit more platelets  Aggregate to form loose platelet plug • Coagulation • Exposed collagen and tissue factor initiate formation of fibrin o Reinforces platelet plug, forming a clot o Fibrin results from coagulation cascade (enzymatic reaction) o Chemical factors promote aggregation and adhesion • Plasmin dissolves fibrin as vessel heals, clot retracts • Too much hemostasis creates thrombin • Blood clot that adheres to undamaged vessels • Platelet activation beings clotting process • When blood vessel wall is damaged, collagen is exposed due to damaged endothelium, activating platelets • Platelets rapidly adhere to collagen with intigrins • Membrane receptor proteins linked to cytoskele
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