PSL301H1 Chapter Notes -Thrombopoietin, Bilirubin, Leukopoiesis
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PSL301H1 Full Course Notes
Verified Note
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Document Summary
Monocytes - leaves circulation & enter tissues to become. Interleukins: given off of wbc to another wbc. Colony-stimulating factors (csfs): made by endothelial cells, wbc, marrow fibroblasts & affect all blood cells. Leukemia (too much wbc) vs neutropenias (too little. Erythropoietin (epo): made in kidney & affects rbc. Released when hypoxia: low oxygen levels in tissues --> makes. Tf hypoxia-inducible factor 1 (hif-1) to turn epo gene on to make epo. -> epo puts more hemoglobin into circulation to carry oxygen. Acts as endocrine cell = made when needed, not stored. Thrombopoietin (tpo): made in liver/kidney & affects megakaryocytes megakaryocytes (to become platelets/thrombocytes) The active regions will make mostly wbc over rbc, cuz wbc have shorter life so they must be replaced frequently. Mitochondria) disappear --> reticulocyte --> leaves marrow and enter circulation --> matures into erythrocyte: mature rbc is a biconcave bag filled w/ enzymes & hemoglobin.
