Biochemistry 2280A Chapter Notes - Chapter 20: Cell Cycle Checkpoint, Cervical Cancer, Mutation Rate
23 Dec 2016
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Document Summary
Cancer cells have two heritable properties: they proliferate in defiance of the normal constraints, they invade and colonize territories normally reserved for other cells. Form secondary tumors or metastases at other sites. The more widely it spreads the harder it is to eradicate. Ionizing radiation: cervical cancer - infection of the human papillomavirus. It arises as a consequence of pathological changes in the information carried by. Mutations underlying cancer are mainly somatic mutations. Spontaneous mutations occur at a rate of 10-6 and 10-7: but it takes more than a single mutation (need like 10 ish, these mutations don"t occur all at once but over a long period of time. Why cancer is a disease of old age. The mutations that lead to cancer give the cells a competitive advantage over their neighbors. As an initial population of mutant cells grow, they evolve: new chance mutations occur some of these are favoured since they enhance cell proliferation and survival.
