Biochemistry 2280A Chapter Notes - Chapter 20: Antibody, Knockout Mouse, Catenin
8 Aug 2016
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Biochemistry 2280 topic 24 molecular basis of cancer. 20 cell communities: tissues, stem cells, and cancer. Tissues are organized mixtures of many cell types. Most tissues have blood vessels lined with endothelial cells, schwann cells around axons, macrophages for clean-up, etc. How tissue organization is maintained: cell communication. Each type of specialized cell looks out for signals, acts accordingly. Ensures new cells produced only when required: selective cell adhesion. Cells stick selectively according to hemophilic binding (binding between same type of cells) Cells also form selective attachments to other cell types and extracellular matrix components. This prevents cells in tissue from getting jumped: cell memory. Gene expression patterns established during embryonic development maintained throughout i. e. fibroblasts only produce more fibroblasts. Most nerve cells last lifetime, intestinal epithelium renewed 3-6 days. Stem cells generate continuous supply of terminall differentiated. Terminally differentiated: cells that cannot divide, at end of developmental pathway: ex. Red blood cells cannot produce more red blood cells.
