Biology 2581B Chapter Notes - Chapter 22-26: Lipase, Ellipse, Transgenesis

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Suggested readings and example questions for lectures 22-26. Questions 4, 5: when a stem cell in the heart divides, it gives rise to a new stem cell and a cell that will divide to become cardiac muscle cells. We have identified and isolated a gene that is required for the decision to remain a stem cell or become committed to give rise to cardiac muscle. A loss-of-function allele in this gene results in no cardiac muscle cells because the stem cell divides to give rise to two new stem cells. The mrna for this gene is found in both stem cells and cells that will give rise to cardiac muscle cells. The mrna has the same exon structure in both the stem cells and muscle cells. The protein is present in the cell that will give rise to muscles only, and not the stem cell.

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