Biology 1001A Chapter Notes - Chapter 23: Intermediate Filament, Chromosome Segregation, Kinetochore

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28 Aug 2017
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Microtubules are made of tubulin, intermediate filaments are made of keratin, microfilaments are made of actin. In metaphase, motor proteins attached to kinetochores grab onto the microtubules (spindle fibres) and pull the chromosomes along to either pole of the cell. The spindle fibre does not pull the chromosomes towards it; rather the chromosomes pull themselves towards the spindle fibre. Motor proteins attached to kinetochores pull the chromosomes apart to the poles. They walk the kinetochore along the microtubules, which disassemble, which in turn pulls the chromosomes towards the poles. 3 checkpoints in cycle: first one is just before s phase: cells will not enter s phase until all of the dna is repaired any damaged dna must be fixed before it is copied in s phase. Second checkpoint is just before mitosis: cells do not enter mitosis until the chromosomes are condensed and ready.

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