Biology 1002B Chapter Notes - Chapter 3-6: Dna Mismatch Repair, Dna Repair, Reverse Transcriptase
31 Oct 2018
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Cycle 3 inheritance of sameness: mechanism of proofreading. The mismatched is recognized since it forms a distortion in dna structure. Repair enzymes removes a section of a mismatched pair and then removes a section, break covalent bonds in the backbone. Mobile elements increase genetic variability through mutation thus are considered biological mutagens, they can cause mutation. So many in body: general trends in costs of dna sequencing. The cost of dna sequencing has decreased as a result of technology improving an finding better methods to sequence dna. Less than 1000$ now, 200$: relative distribution of various components of genome sequence (junk vs. essential dna) Only 10% of dna is useful and 2% is coding enq: proportion of human genome coding for protein. Protein coding is only in 2% of the human genome: difference between dna damage and mutation. Dna damage is repairable while mutation is not. Mutation is a double stranded change in the dna sequence.
