Biology 1002B Chapter Notes - Chapter 13: Signal Transduction, Cell Membrane, Chromosome
6 Mar 2016
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Developmental biologists interested in identifying and characterizing genes involved in. Defining how gene products regulate and bring about elaborate events development o. Model organism: drosophilia and c. elegans and zebrafish (danio rerio) and house. Analyze genes in detail to build models for molecular products in development mouse (mus musculus) o. Gene expression regulates changes that occur through determination and differentiation o. Ex. genetic control of processes is production of skeletal muscles cells from somites in mammals. Somites are blocks of mesoderm cells that form along both sides of notochord. Under genetic control, some cells of each somite differentiate into skeletal muscles. Paracrine: signaling from nearby cells induces somite cells to express regulatory gene myod. Brings about determination of these cells, converting undifferentiated muscle cells called myoblasts: an undifferentiated muscle cell. Both regulatory genes: expressing transcription factors in myoblasts that turn on yet another set of genes. Products of genes promote differentiation of myoblasts into specific muscle tissues.
