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BIOL 2905 (101)

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BIOL 2905
Motti Anafi

microbiology natural: exposure to sub-clinical infections. artificial life attenuated vaccines the virulent parental vaccines the virus in the vaccine must be alive to replicate in the vaccines cells • storage ex: opv with vaccines vial monitor • maternal antibodies • risk for back mutations the attenuated virus can infect non vaccinated people better herd immunity polio risk to immuno compromised people eg. influenza • with influenza the virus mutates every year therefore the vaccine must change. mmr: measles, mumps, rubella, people must get it every year. • rna viruses but genetically stable • no back mutations safe vaccines for everybody • human host only influenza since 2003 • for healthy and young people varicella zoster • chicken pox in kids • shingles in adults greater lesser than 60 years polio sabin very common until 90's killed vaccines • virons inactivated by chemical procedures • ineffectively and viral ability to replicate are eliminated but antigenicity is not compromised Polio (slak) • at present - very common use Influenza: • new strain every year hepatitis a rabies • even post exposure infection by rabies virus • replication- transport- replication- transsynaptic spread- axon - uptake (graph) toxoids inactivated toxoids 1. diahtheria 2. tentanus sub cellular/ small fragments the virulent parental virus • fraction • purified subunit vaccine hepatitis b virus- A fragment vaccine first generation - extracted from the blood plasma of hepatitis patients today: cloned in yeast (coding using yeast/bacterial cell, expression: as mention above) rabies product i g use: post exposure locally administered disease: cytomegalovirus product: hyper immune human ig use: prevention used most often in organ transplantation patients. give the baby anti bodies against cytomegalovirus disease: hepatitis a product: pooled human ig use: prevention of hepatitis a infection disease: hepatitis b n product: hepatitis b ig use: prevention in high risk infants administered with hepatitis b vaccine. blood to blood transmission, sexual contact, from mother to new born, new born babies don't have immune to this virus at this stage. first give the baby a boost of antibodies, bunch of vaccines given earlier are going to protect the baby from infect 72hr after birth. vaccination with antigen in administered, 2moths a second boost, then 6months anot
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