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BIOL 3120 (12)
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Week 12 pt3.docx

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Department
Biology
Course
BIOL 3120
Professor
All Professors
Semester
Fall

Description
3. The early response occurs within minutes of allergen exposure and results from the release of histamine (vasodilation), leukotrienes (bronchoconstriction), and prostaglandins (mucus secretion) from local mast cells. In the late-phase reaction, cytokines released from mast cells, particularly TNF-α and IL-1, increase the expression of cell adhesion molecules on venular endothelial cells, thus facilitating the influx of neutrophils, eosinophils, and TH2 cells that characterizes this phase of the response. Eosinophils play a principal role in the late-phase reaction. Eosinophil chemotactic factor, released by mast cells during the initial reaction, attracts large numbers of eosinophils to the affected site. This leads to degran
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