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Week 12 pt7.docx

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Department
Biology
Course
BIOL 3120
Professor
All Professors
Semester
Fall

Description
18. Central Tolerance:Elimination of self-reacting lymphocytes in primary lymphoid organs (thymus, bone marrow) before completing their maturation Peripheral Tolerance: Renders the activity of self-reactive lymphocytes in secondary lymphoid tissues, different mechanisms: 1. Treg cells (selected for binding strongly to self-antigens) - Both contact dependant and contact independent mechanisms - CD4+ TREG cells have been shown to killAPCs or effector T cells directly, by means of granzyme and perforin - Can modulate the function of other cels by surface receptor engagement (interaction of CTLA-4 on TREG cells with CD80/86 onAPC => Inhibition ofAPC) - They can secrete different inhibitory cytokines - Linked suppression: In cases where a single antigen-presenting cell (APC) engages simultaneously with T cells of different specificity, inhibitory signals meant for one can be transmitted to both and lead to a “spreading” of immune suppression to include other
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