PSC 433 Chapter Notes - Chapter 15: Topiramate, Zonisamide, Felbamate
17 Feb 2019
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Drugs used to treat epilepsy: primary drugs: carbamazepine, clonazepam, clorazepate, diazepam, ethosuximide, lorazepam, Oxcarbazepine, phenobarbital, phenytoin, primidone, valproic acid: adjunct drugs: felbamate, gabapentin, lamotrigine, levetiracetam, tiagabine, topiramate, Zonisamide: broad spectrum: valproic acid, felbamate, lamotrigine, topiramate, zonisamide, few or no drug interactions: gabapentin, levetiracetam, topiramate, requires slow adjustment to therapeutic levels: zonisamide, topiramate, lamotrigine, possibility of rare, life-threatening adverse effects: lamotrigine, felbamate, valproic acid, Overview: the second most common neurologic disorder after stroke, epilepsy is a family of different recurrent seizure disorders that have in common the sudden, excessive, and synchronous discharge of cerebral neurons. The electrical discharge does not spread, and the patient does not loose consciousness. The patient often exhibits abnormal activity of a single limb or muscle group that is controlled by the region in the brain experiencing the disturbance. The patient may also show sensory disturbances: complex partial: these seizures exhibit complex sensory hallucinations, mental distortion, and loss of consciousness.
