CAS BB 191 Chapter Notes - Chapter 20: Pyruvate Dehydrogenase Complex, Atp Synthase, Cellular Respiration
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Cellular respiration overall an oxidative, exergonic process ( g = -686 kcal/mole) External respiration is entry of air into lungs and gas exchange between alveoli and blood; internal respiration is exchange of gas between blood and the cells + intracellular respiration processes. During respiration, high energy h atoms removed from organic molecules (dehydrogenation) C6h12o6 + 6o2 6co2 +6h2o + energy. Aerobic respiration = in the presence of o2 (glycolysis, pyruvate decarb, krebs cycle, oxidative phosphorylation); water is the final product. Glycolysis decomposition of glucose into pyruvate in cytosol: 2atp added, 2nadh produced, 4 atp produced, 2 pyruvate formed. Net: 2 atp + 2 nadh + 2 pyruvate (+2 h2o + 2 h+: atp produced here via substrate level phosphorylation. Pyruvate decarboxylation: at this point we are in the mitochondrial matrix, pyruvate to acetyl coa, producing 1 nadh and 1 co2. Net: 2 nadh + 2 co2: catalyzed by pdc enzyme (pyruvate dehydrogenase complex)