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Chapter 6.8-6.14

CAS BI 315 Chapter Notes - Chapter 6.8-6.14: Postsynaptic Density, Excitatory Synapse, Electrical Synapse

Course Code
CAS BI 315
Angela Seliga

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Reading 8: 6.8-6.14
Electrical synapse plasma membranes of pre/postsynaptic cells are joined at gap junctions
Currents flow directly across junction into next cell
Depolarizes membrane of second cell action potential
Chemical synapse axon of presynaptic neuron ends in bulge containing synaptic vesicles and
Postsynaptic membrane has high density of proteins making up postsynaptic density
Synaptic cleft extracellular
space separating pre/post
synaptic regions; prevents
direct communication
accomplished using
Vesicles contain NTs are docked on
membrane active zones released
upon action potential
Contain VG Ca2+ channels opening
leads to Ca2+ influx at terminal
activation of synaptotagmins fusion
of docked vesicles release of NTs
NTs bind to active sites on postsynaptic
Ionotropic receptors NT
activated ion channels
Metabotropic receptors GPCRs
activated by NT opens ion
Lead to activation of ion
channels regardless of the
Synaptic delay 0.2 ms between
arrival of action potential and
potential changes in post cell
Transient and reversible event
after activation NT uptake,
diffusion, or inactivation occurs
Excitatory synapse postsynaptic
response is depolarization; opening of Na+ and K+ channels; EPSP
Inhibitory synapse postsynaptic response is hyperpolarization; opening of K+ or Cl-; IPSP
Temporal summation summation of IPSP and EPSP de/hyperpolarizations at different times
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