GEN-3000 Chapter Notes - Chapter 18-19: Whole Genome Sequencing, Structural Genomics, Transcriptomics Technologies
13 Dec 2017
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Document Summary
Genomics: field of genetics used to understand content, organization, function and evolution of genetic information in an entire genome. Comparative genomics: similarities and differences in gene content, function and organization among genomes of different organisms. Structural genomics: organization and sequence of genetic information within a genome. Focuses on sequencing genome and analyzing nucleotide sequences. Shotgun cloning: method of sequencing involving fractioning up the genome and sequencing it. Helps read data obtained from shotgun sequence or map sequence. Describe function and interactions of genome and phenotype. Looks at transcription, translation, expression and protein-protein interaction. Transcriptomics: analysis of all expressed genes in a cell or tissue. Proteomics: analysis of all proteins in a cell or tissue. Gene deserts: large areas with no known genes. System biology: incorporates data from genomics, transcriptomics, proteomics and other biology areas. Interprets genomic information in context of structure, function and regulation of bio pathways. Help biologist build a system level understanding of organism function.
