NRSC 4032 Chapter Notes - Chapter 3: Nmda Receptor Antagonist, Nmda Receptor, Second Messenger System
Document Summary
The synapses as a biochemical factory: all the proteins that are present at the postsynaptic neuron that are necessary should be there, if there is a missing protein this can lead to disruption. First messenger --> second messenger --> proteins --> kinases or phosphatases --> structural and functional proteins. First messenger: nts that bind to a receptor on the membrane (metabotropic or ionotropic) Second messenger: amplifies the effect of first messengers. Molecules that relay the information from receptors intracellularly . They target kinases and phosphatases: kinases- a catalytic subunit and inhibitory or regulatory subunit. In its inactive state the catalytic unit is unable to phosphorylate: to activate the kinase, the secondary messenger must inhibit its inactive state. The kinase then adds a phosphate group to other proteins, changing their function: phosphatases- they remove phosphate groups. Ionotropic receptors play a major role in ltp. Ionotropic receptors - neurotransmitter binds-> opening channel to allow the flow of ca2+ or.
