BIO 226 Chapter Notes - Chapter 20: Aciclovir, Thymidine, Deoxyguanosine
31 Oct 2018
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Inhibit dna or rna synthesis or reproduction. Nucleoside analog- artificial nucleoside which, when incorporated into viral dna during replication, inhibits production of new virus. The enzyme thymidine kinase combines phosphates with nucleosides to form nucleotides, which are then incorporated into. Acyclovir has no effect on a cell infected by a virus, that is, with normal thymidine kinase. In a virally infected cell, the thymidine kinase is altered and converts the acyclovir (which resembles the nucleoside deoxyguanosine) to a false nucleotide, which blocks. Nucleotide analog- artificial nucleotide which, when incorporated into viral dna during replication, inhibits production of new virus. Haart- potent treatment composed of drug combinations to suppress the growth of hiv. Interferons (cytokines)- prevent spread of viruses to new cells. Protease inhibitors- block the enzymatic cleavage of protein precursors during viral replication. Fusion inhibitors- prevent entry of hiv into the cell.
