MCB 2000 Chapter Notes - Chapter 15: Tetanus, Macrophage, Cell-Mediated Immunity

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Specific immunity: when the non-specific defense fails, then the third, specific line of immunity is activated, immunity is not innate but adaptive; it is acquired over time, it is characterized with a specificity and memory. Specificity antibodies against chickenpox is not effective against measles virus. Antigen processing cells (apc) ingest a bacterial cell degrade the antigen into smaller peptides. The processed antigens are complexed with a cell glycoprotein mhcii (major histocompatibility complex) and transported to the cell surface: antigen presentation. The processed antigens are presented to lymphocytes. T cells are activated they release interleukin-2. B-cell activation and antibody synthesis: the linked receptor of t-cells and b-cells, and chemical stimulus from the t-cell stimulates the b-cells, proliferation and differentiation of b-cells, two types of cells are formed: memory cells and plasma cells. Memory cells play role in future exposure to the same antigen. Plasma cells synthesize and release the antibodies.

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