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Chapter 15

NUR 239 Chapter Notes - Chapter 15: Antiplatelet Drug, Aspirin Poisoning, Salicylic Acid


Department
Mennonite College of Nursing
Course Code
NUR 239
Professor
Yvette Pigman
Chapter
15

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You should have an understanding of all the key terms at the beginning of each Chapter.
Key Learning Objectives - Answer the follow questions (Chapter 15 – Inflammation, Infection, and
Use of Antimicrobial Agents): Only covering Overview of Inflammation (p. 283 – 285) in Unit 1
What are the causes (etiology), pathophysiology and clinical manifestations of Inflammation?
Describe the stages of acute inflammation.
What are the two types of chronic inflammation?
The rest of Chapter 15 will be covered in Unit 2
Key Learning Objectives - Answer the follow questions (Chapter 16 – Drug Therapy to Decrease Pain,
Fever, and Inflammation):
What are prostaglandins?- are chemical mediators found in most body tissues; they help
regulate mediators found in most body tissues; they help regulate many cell functions and
participate in inflammatory response
What Drug classes are considered anti-prostaglandins? Nonsteroidal anti-inflammatory drugs
(NSAIDS)
The COX enzyme metabolize arachidonic acid and produce prostaglandins. Identify the two
types, where they are primarily found, and their purpose.
Define pain, fever, and inflammation.
Inflammation is the normal body response to tissue damage from any source, and it may occur
in any tissue or organ. It is an attempt by the body to remove the damaging agent and repair the
damaged tissue
Pain is the sensation of discomfort, hurt or distress
Fever is an elevation in body temperature above the normal range
What is salicylate toxicity called? How is it treated?
Salicylism
How is an acetaminophen overdose treated?
Anti-
Inflammatory
Drugs
Salicylates Non-Narcotic
Analgesic
Antipyretic
Propionic
Acid
derivatives
Oxicam
Derivati
ves
Acetic Acid
Derivatives
Selective
COX-2
Inhibitor
Prototype Drug aspirin acetaminophen ibuprofen meloxic
am
indomethacin celecoxib
Pharmacokinetics 5-10 minutes
Orally or 15-
Orally. Peak at
30 to 120
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