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Mark Siegal (12)

Textbook Notes for Mark Siegal

Molecular and Cell Biology I

Exam Study Guides for BIOL-UA 21

Covers all exam topics.

BIOL-UA 21 Chapter Notes - Chapter 7: Protein Structure, Alpha Helix, Repressor
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pgs. 306-315, 318-323 7.4 Regulatory Sequences In protein Coding Genes and the Proteins Through Which They Function ● Repressor Inhibit Transcription and Ar the Functional Converse of Activators ○ euka...

Biology
BIOL-UA 21
Mark Siegal
BIOL-UA 21 Chapter Notes - Chapter N/A: Liposome, Zebrafish, Cullinet
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A guide to genome engineering with programmable nucleases ● Programmable nucleases [ie = zinc-finger nucleases, transcription activator-like effector nucleases, and RNA-guided engineered nucleases) derived ...

Biology
BIOL-UA 21
Mark Siegal
BIOL-UA 21 Chapter Notes - Chapter 7: Euchromatin, Transcription Preinitiation Complex, Elongation Factor
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7.5 Molecular Mechanisms of Transcription Repression and Activation ● the repressors and activators that bind to specific sites in DNA and regulate expression of the associated protein-coding genes do so by t...

Biology
BIOL-UA 21
Mark Siegal
BIOL-UA 21 Chapter Notes - Chapter 7: Phosphodiester Bond, Transfection, Affinity Chromatography
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pgs. 288-290, 303-306 7.2 Overview of Eukaryotic Gene Control ● Regulatory Element sin Eukaryotic DNA Are Found Both Close to and Many Kilobases Away from Transcription Start Sites ○ regulation ...

Biology
BIOL-UA 21
Mark Siegal
BIOL-UA 21 Chapter Notes - Chapter 1: Pax6, Plasmodesma, Zebrafish
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1 Lecture 1 Notes pgs. 1-22 Introduction 1-4 ● Genes: are chemically composed of DNA, define biological structure and maintain the integration of cellular function. ● Proteins: genes encode proteins wh...

Biology
BIOL-UA 21
Mark Siegal
BIOL-UA 21 Chapter Notes - Chapter 4: Ethyl Methanesulfonate, Metastasis, Chemotherapy
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pgs. 151-156 4.6 DNA Repair and Recombination ● DNA damage can be caused by: ○ spontaneous cleavage of chemical bonds in DNA ○ environmental agents ie ultraviolet and ionizing radiation ...

Biology
BIOL-UA 21
Mark Siegal
BIOL-UA 21 Chapter Notes - Chapter 5: Genetic Distance, Centimorgan, Tryptophan
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Molecular Genetic Analysis I: Gene Discovery in Model Organisms assigned: 172-182 (Sec 5.1) 5.1 Genetic Analysis of Mutations to Identify and Study Genes ● Terminology: ○ allele = different forms or ...

Biology
BIOL-UA 21
Mark Siegal
BIOL-UA 21 Chapter Notes - Chapter 6: Trisomy, Chromosome Territories, Ndc80
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6.6 Structural Organization of Eukaryotic Chromosomes: Histone = nuclear proteins responsible for compacting and organizing chromosomal DNA ● Chromatin = complex of histones and DNA ○ Chromatin which ar...

Biology
BIOL-UA 21
Mark Siegal
BIOL-UA 21 Chapter 7: Meeting 13
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assigned readings: 7.07.2 Chapter 7: Transcriptional Control of Gene Expression regulation of gene expression is the fundamental process that controls the development of multicellular organism from a single fertilized egg ...

Biology
BIOL-UA 21
Mark Siegal
BIOL-UA 21 Chapter Notes - Chapter 7: Atp Hydrolysis, Cyclin-Dependent Kinase 9, Transcription Factor Ii F
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pg. 295-302 7.3 RNA Polymerase II promoters and General Transcription Factors - the mechanisms that regulate transcription initiation and elongation by RNA polymerase II have been studied extensively becau...

Biology
BIOL-UA 21
Mark Siegal
BIOL-UA 21 Chapter Notes - Chapter 5: Wild Type, Monogenetic Volcanic Field, Northern Blot
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pgs. 206-211 5.4 Locating and Identifying Human Disease Genes ● typical first step in deciphering cause for any inherited human disease is to identify the affected gene and its encoded protein ○...

Biology
BIOL-UA 21
Mark Siegal
BIOL-UA 21 Chapter 5: Meeting 16
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5.5 Inactivating the Function of Specific Genes in Eukaryotes pp. 212219 I.Normal Yeast Can Be Replaced with Mutant Alleles by Homologous Recombination Genome of yeast S. cerevisiae is easy to modify because: 1.yeast cells...

Biology
BIOL-UA 21
Mark Siegal

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