Textbook Notes (368,432)
United States (206,039)
01:119:115 (54)
D'arville (5)
Chapter 46

Ch. 46 Book Notes

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Department
Biological Sciences
Course
01:119:115
Professor
D'arville
Semester
Spring

Description
Ch. 45 Book Notes Vertebrates: non­specific immune  Innate immunity: immune responses always present to protect against pathogens,  toxin, drugs, and cancer cells  Actions:  o Physical barriers: skin, cuticle, shell o Pattern recognition receptors: recognize PAMPs   PAMPs:   stimulate non­specific immune responses, sahred by each  group of microbes (pathogens, viruses)   Toll­like recepto : activate certain transcription factors o Cells (phagocytes):    Neutrophil : white blood cells   Natural killer (NK) cel  originate in bone marrow, active against  tumor cells, and cells infected with viruses.  • Release: Perforins: enzymes that cause pores to form In  plasma membrane, allowing granzymes to enter and self  destruct the cells o Protein:    Cytokines  signaling molecules, perform regulatory functions • Interferons o Type 1: inhibit viral replication and activate NK  cells o Type 2: stimulate macrophages • TNF: stimulate immune cells to initiate inflammatory  response • Inter
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