Textbook Notes (290,000)
US (110,000)
Rutgers (1,000)
12:34 (5)
F.Deis (2)
Chapter 15

01:694:301 Chapter Notes - Chapter 15: Myoglobin, Porphyrin, Glycogen Phosphorylase


Department
Molecular Biology and Biochemistry
Course Code
01:694:301
Professor
F.Deis
Chapter
15

This preview shows pages 1-3. to view the full 13 pages of the document.

Only pages 1-3 are available for preview. Some parts have been intentionally blurred.

(
favorable
)
HIGH
ENERGY
why
is
there
LARGE
SG
¥
of
phospho
transfer
potential
ATP
HYDRO
L
Y
S
l
S
is
FAVORABLE
8
1)
resonance
stabilization
lowers
SG
more
stable
(
e
-
run
freely
over
molecule
)
not
confined
in
1
place
2)
loss
of
charge
-
charge
repulsion
°
ATP
to
ADP
reliefs
electrostatic
repulsion
btwn
neg
P
groups
3)
tautomer
iz
a
ti
o
n
isomerize
's
into
more
stable
form
(
ketone
)
-
stabilized
by
:
loss
of
p
-
tautomer
izes
ketone
(
MTF
able
)
4)
better
solvation
of
products
than
reactants
5)
greater
#
particles
greater
entropy

Only pages 1-3 are available for preview. Some parts have been intentionally blurred.

ENZYME
want
to
regulate
activity
REGULATION
+
functionality
of
25
,
28
-
31
enzymes
FACTORS
THAT
IN
F
L
U
E
N
C
E
ACTIVITY
S
U
B
S
T
R
A
T
E
t
C
O
FA
C
T
OR
AVAILABILITY
o
availability
of
substrates
+
cofactor
determines
enzymatic
rxh
rate
°
enzymes
evolved
availability
near
km
PRO
D
U
LT
ACCUMULATION
°
rate
slows
as
product
accumulates
t
equilibrium
approached
°
Req
reached
,
nothing
further
occurs
enzymes
don't
affect
thermodynamics
S
Y
N
T
H
E
S
l
S
AND
DE
G
R
A
DA
T
t
O
N
O
F
E
N
Z
Y
M
E
"
day
:
a°on
of
enzyme
synthesis
)÷¥÷÷÷s÷
repression
shutdown
of
enzyme
synthesis
I
¥
g
'
by
controlling
amt
of
enzyme
present
,
cells
can
activate
)
terminate
metabolic
routes
C
O
V
A
L
E
N
T
M
O
D
l
F
l
C
A
T
l
O
N
°
covalently
attach
a
group
onto
enzyme
THIS
changes
activity
of
enzyme
(
can
turn
OFF
/
ON
enzyme
)
PHOSPHORYL.AT#
PRO
T
E
I
N
KI
N
A
S
ES
responsible
for
phosphorylation
(
inactivates
enzyme
)
P
R
O
T
E
l
N
P
H
O
S
P
H
A
T
ASE
de
phosphorylates
,
enzyme
reactivates
e"4Ei
Enzyme
-
P
+
ADP
E
N
Z
Y
M
E
t
AT
P
Bon
tix
reactivates
#
A
PROTEIN
pH
OS
P
t
You're Reading a Preview

Unlock to view full version