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Textbook Notes for Biochemistry at Syracuse University (SU)


SYRACUSEBCM 475WelchFall

BCM 475 Chapter Notes - Chapter 21: Glycogen Phosphorylase, Carbonium Ion, Pyridoxal Phosphate

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Glycogenn + pi glucose 1-phosphate + glycogenn-1. Phosphorolysis - cleaves glycosidic bond between c1 and c4 by adding pi: replaced with a phosphoryl e
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SYRACUSEBCM 475WelchFall

BCM 475 Chapter Notes - Chapter 21: Phosphorylase, Glycogen, Skeletal Muscle

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Phosphorylase is regulated by several allosteric effectors (signal energy state of cell) and. Phosphorylase regulation reversible phosphorylation: resp
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SYRACUSEBCM 475WelchFall

BCM 475 Chapter Notes - Chapter 16: Dihydroxyacetone Phosphate, Hexokinase, Ketose

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Step 1 phosphorylation | hexokinase traps glucose in the cell glycolysis begins. Phosphorylated by atp to form glucose-6-phosphate: cannot pass through
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SYRACUSEBCM 475WelchFall

BCM 475 Chapter Notes - Chapter 17: Acetyl-Coa, Thioester, Oxaloacetic Acid

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Final common pathway for oxidation of fuel molecules. Harvests high energy e- from fuel (acetyl coa) to electron carriers (nadh and fadh2) Acetyl coa +
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SYRACUSEBCM 475WelchFall

BCM 475 Chapter Notes - Chapter 21: Glycogen Phosphorylase, Glycogen Synthase, Glycogenesis

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Synthesis: glucose 1-phosphate + glycogenn + utp + h2o glycogenn+1 + udp + 2pi. Degradation: glycogenn+1 + p glycogenn + glucose-1-phosphate. Benefits
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SYRACUSEBCM 475WelchFall

BCM 475 Chapter Notes - Chapter 11: Glycosaminoglycan, Glycoprotein, Glycosylation

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Glycosylation increases proteome complexity: protein with numerous glycosylation sites can have different glycosylated forms. Many proteins secreted fr
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SYRACUSEBCM 475WelchFall

BCM 475 Chapter Notes - Chapter 12: Methylene Group, Choline, Phospholipid

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Prevent leaking/entering of unwanted molecules: lipid components form barrier of permeability and protein components form pumps/channels. Fuel molecule
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SYRACUSEBCM 475WelchFall

BCM 475 Chapter Notes - Chapter 16: Pyruvic Acid, Nicotinamide Adenine Dinucleotide, Acetaldehyde

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Glycolysis | metabolism of 1 glucose into 2 pyruvate; with net production of 2 atp. Anaerobic pyruvate can be further generated to form lactate: aerobi
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SYRACUSEBCM 475WelchFall

BCM 475 Chapter Notes - Chapter 20: Ribulose, Transketolase, Pentose

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Source of nadph for use in reductive biosynthesis and in protection against oxidative stress. Excess 5-carbon sugars can be converted into intermediate
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SYRACUSEBCM 475WelchFall

BCM 475 Chapter Notes - Chapter 17: Thiamine Pyrophosphate, Acetyl-Coa, Lipoamide

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Aerobic conditions: pyruvate transported into mitochondria for oxidative decarboxylation. Pyruvate + coa + nad+ acetyl coa + co2 + nadh + h+ Large, int
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SYRACUSEBCM 475WelchFall

BCM 475 Chapter Notes - Chapter 11: Anomer, Glycated Hemoglobin, Glycosidic Bond

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Carbohydrates supply details/enhancements to biochemical architecture of cell. Glycobiology study of synthesis, structure of carbs; attachment/recognit
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SYRACUSEBCM 475WelchFall

BCM 475 Chapter Notes - Chapter 8: X-Ray Crystallography, Atp Hydrolysis, Enzyme Kinetics

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Enzymes are special because of their catalytic power and specificity. Proteins are highly effective catalysts for a wide variety of chemical reactions
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