BICH 410 Chapter Notes - Chapter 8: Non-Competitive Inhibition, Suicide Inhibition, Catalytic Cycle
Document Summary
Enzymes maintain physiological reactions by exerting kinetics control over the thermodynamic potentiality of a reaction. Enzymes have sites that are complementary to substrate both in geometry and electronic con guration. Even though the site has speci c standards it is possible for multiple different substrates to bind to that one speci c spot. Each substrate is able to have their own response though. Enzymes usually require the presence of metal ions or small organic molecules to function. Non-protein component - cofactor ( or coenzyme) cosubstrate- only transiently associated with enzyme prosthetic group- describes a complex in which the small organic molecule is bound to the apoenzyme by covalent bonds. Many prosthetic groups and coenzymes are water soluble derivatives of vitamins. *many clinical symptoms of dietary vitamin insuf ciency generally arise from the malfunction of enzymes which lack suf cient cofactors to maintain required physiological activity. Metalloenzymes- enzymes that bind metal ions with high af nity.