105 Metabolic Pathways Notes.docx

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University of Maryland
Biological Sciences Program
BSCI 105
Patricia Shields

Glycolysis- cell cytoplasm Krebb Cycle- matrix surrounded by inner membrane ETC in inner membrane of mitochondria Glycolysis only gain net of 2 ATP - Oxygen available- enter krebb cycle and enter ETC - w/o oxygen- glycolysis only, no krebb or etc - by- product molecules used in ETC and krebb (2 ATP, 2 NADH, 2 Pyruvate) ATP due to substrate level phosphorylation (Substrate binds to enzyme where ADP is found, catalyze transfer of phosphate from substrate to ADP, when gains phosphate, generate ATP) - energy needed to make ATP derived from breaking of covalent bonds result in ADP being phosphorylated - Doesn’t require oxygen (why only in glycolysis) Krebb Cycle - generate 2 ATP (1 per turn), then enter ETC - go around twice b/c have 2 pyruvate molecules metabolized by glycolysis - If need energy- transport pyruvate to mitochondria, active transport - In mitochondrial matrix pyruvate dehydrogenase complex convert pyruvate molecules into acetyl coa Pyruvate molecule enter mitochondria through active transport- lose oxygen and 1 carbon CO2, nad+ reduced, left with acetyl group that associates w/ coenzyme a to produce acetyle coa (produced by oxidation of pyruvate) - Nadh enter mitochondria through active transport, costs 1 atp for each to be transported (use up 2 ATP) - 2 atp, 6 nadh, 4co2, 2fadh2 molecule generated from two turns of krebb - Molecules used as electron carriers in ETC (NADH, FADH2) CO2 produced during krebb and glycolytic pathway not used for energy creation, is low energy molecule Electron Transport Chain set of oxidation/ reduction reaction in inner mitochondrial membrane - Produces a lot of ATP so metabolic processes in body can be complete - Powerhouse of cell 4 protein complexes embedded in inner mitochondrial membrane - ATP Synthase- not part of ETC, is responsible for chemiosmosis (transport of ions across selectively permeable membrane) Process of electron transport + ATP synthase makes up oxidative phosphorylation (process of electron transport, proton move across membrane, ATP generation) - Protons in intermembrane space- electrons pass through complexes, protons pumped from matrix to space) o Carriers NADH and FADH2 lose hydrogen when reach complexes and become oxidiz
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