MIEH 300 Chapter Notes - Chapter 3: Lethal Dose, Environmental Toxicology, Exposure Assessment

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The study of adverse effects of agents on living organisms: seeks to understand formation, composition and properties of harmful toxic substances, determines specific molecular and biochemical mechanisms. Important discipline for protecting human health and the environment. Study of how ecological systems (their structure, dynamics etc. ) are affected by pollutants. Special concern on release of toxic pollutants into the environment especially aquatic systems. Distributed through toxic levels of food chain. Effects of xenobiotics (foreign agents not found in the body) on biological systems: dose is the amount of substance administered at one time. Lethal dose: (ld50) is the dosage causing death in 50% of exposed organism. Others include ld10 and ld90, 10% and 90% mortality respectively. Lethal dose rarely used because there are safer ways to test dose. Correlative study between characteristics of exposure to chemicals and spectrum of effects caused by that chemical. Factor affecting responses to a toxic chemical.

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