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Chapter 2

BIL 250 Chapter Notes - Chapter 2: Dna Replication, Mutation, Polysaccharide


Department
Biology
Course Code
BIL 250
Professor
Kevin Mc Cracken
Chapter
2

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CHAPTER 2
Griffith’s Trasforatio Eperiet 
S strain of bacterium
Smooth, shiny colonies
Virulent (highly infectious)
Polysaccharide coat
IIS and IIIS
R Strain of bacterium
Rough colonies
Nonvirulent
Mutation for no polysaccharide coat
To kill the mice: bacteria had to be alive and have the polysaccharide coat
Transforming Principle: material bringing the genetic change
Incorrectly believed that protein was the transforming agent
DIDN’T KNOW WHAT THE AGENT WAS
Aer’s Trasforatio Eperiet 
IIIS DNA as the geeti aterial i Griffith’s eperiets ot RNA
Adding the DNA to bacteria produced IIIS
Hershey-Chase Bacteriophage Experiment (1953)
Bacteriophage: virus that attacks bacteria
**Deciphered DNA, not protein was the genetic material that transformed in
Griffith’s eperiet
Watson & Crick
Proposed double-helix model of DNA
Bases: A = T, G = C
Main features of Double Helix Model of DNA
Two polynucleotide chains
Antiparallel: 5-3,3-5
Sugar-phosphate backbones on the OUTSIDE, bases towards CENTRAL
Weak H-bonds; A-T (2H) G-C (3H)
Base pairs are 0.34 nm apart
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