BIO SCI E109 Chapter Notes - Chapter 10: Cyclic Adenosine Monophosphate, Cholinergic, Postganglionic Nerve Fibers
7 Oct 2016
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Course bio e109: the autonomic nervous system uses different types of neurotransmitters and receptors. cholinergic neurons and receptors. Cholinergic neurons: all parasympathetic and sympathetic preganglionic neurons, most parasympathetic postganglionic neurons, sympathetic postganglionic neurons that innervate most sweat glands. M1m3m5: smooth muscle&glands activate gq protein and phospholipase c trigger ip3/dag second messenger pathway increase intracellular ca2+ excitation. M2m4: smooth muscle&glands&cardiac muscle activate gi pro inhibits adenylyl cyclase&decrease camp level open k+ channels inhibition. [in heart, m2 receptors activate a gi pro that directly opens k+ channels without altering adenylyl cyclase/camp level] Plasma membrane: dendrites, chromaffin cells of the adrenal medulla(n2) Plasma membrane of the effectors(smooth muscle, cardiac muscle, glands) innervated by parasympathetic postganglionic axons. Name: because nicotin/muscarinie mimics the action of ach. Ache= acetylcholinesterase: quickly breaks down ach, effects triggered by cholinergic neurons are brief enzymatic by adrenergic neurons and receptors. Metabotropic receptors: coupling to g pro respond to the binding of either norepinephrine/epinephrine.
