PCB 3233 Chapter Notes - Chapter 1: Opsonin, Gonorrhea, Serum Amyloid P Component

113 views7 pages

Document Summary

Strategy is to kill the human cells in which the pathogens are living: many pathogens have life cycles that involve both extracellular and intracellular forms. C3 are prone to successive severe infections: when the complement system is activated by infection it leads to the cleavage of c3 into a small c3a fragment and a large c3b fragment. 2-4 at the start of an infection, complement activation proceeds by the alternative pathway. This receptor is called complement receptor 1 or cr1. Impaired synthesis of this tail is the common cause of paroxysmal nocturnal hemoglobinuria, a disease characterized by episodes of complement-mediated lysis of red blood cells that lack cell-surface daf, hrf, or cd59. These changes make it easier for plasma proteins and cells to pass out of the blood into the site of an infection. In some instances the proteases are made by the pathogen; in others the pathogen hijacks a human protease for its own purposes.

Get access

Grade+
$40 USD/m
Billed monthly
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
10 Verified Answers
Class+
$30 USD/m
Billed monthly
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
7 Verified Answers

Related Documents