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Chapter 10

LIFESCI 2 Chapter Notes - Chapter 10: Spindle Apparatus, Sister Chromatids, Kinetochore


Department
Life Sciences
Course Code
LIFESCI 2
Professor
Esdin Joseph
Chapter
10

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Chapter 10 Notes
Why Cell Division is Important
o Reproduction
o Development
o Maintenance of organs
Reproduction
Tissue Repair and Maintenance
o Mouth
o Esophagus
o Stomach
o Small Intestine
Lining of small intestine is replaced every 5 days
o Large Intestine
o Eyhtrocyte
o Leukocyte
o Platelets
Cell Division
o DNA replication
o Separation of DNA
o Regulation and control
Genetic Material
o Linear DNA molecules that are associated with proteins called
histones
o Chromosomes
DNA and proteins
o Eukaryotes hve two copies of each chromosome (homologous)
Diploid (2n)
The Mitotic Cell Cycle
o Interphase
G1, S, G2
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2
o Mitosis
Prophase
Chromosomes condense
Nucleolus disappears
Mitotic spindle begins to form
Prometaphase
Nuclear envelope breaks down
Kinetochores formation occur
o Made of two sister chromatids that are
connected by kinetochores to the spindle
microtubules that are latched at spindle poles
Metaphase
Alignment of chromosomes occurs at metaphase
plate
Distinct form of condensation
Anaphase
Spindle separates chromosomes
o Kinetochore microtubules and non-
kinetochore microtubules consist of mitotic
spindles
o Non Kinetochore Microtubules
Sliding of the nonkinetochore
microtubules pushes poles apart
increasing the total length of the spindle
o Kinetochore Microtubules
Motor protein of the kinetochore of the
chromosome walks along the
microtubule pulling the chromosome
with it
Telophase
Spindle disassembles
Chromosomes decondense
Nucleolus reappears
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