MIMG CM156 Chapter 16: Pharmacogenetics Notes
21 Aug 2016
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* risk/benefit ratio 2: specific for individuals: overview. Pharma : drug = all that we put into our body (i. e. , through mouth) Not everyone has same alleles some excretes/has more proteins (i. e. ,), enzymatic activity, some less. Classic cases: g6pf favism, alcohol flushing: could be recognized because rare variants could be isolated. Rare reason for people being on fence in regards to genetics being important: g6pd favism: have to avoid eating these fava beans (grown on mediterranean coast) b/c can develop hemolytic anemia. Those who make less of variant (g6pd extremely common enzyme) ones who are susceptible to disease. Also ones selected for b/c protects against malaria. Parasite being put in already weakened cells kills them. Males thus, more likely of either getting or not. Also allelic variants, a & b charge difference in protein, fast vs. slow form. Women x-inactivation + heterozygote for ab (mosaic) expressing either type a or type b. Can run on gel to see which type.
