SOC GEN 5 Chapter Notes - Chapter week 1: Dna Gyrase, Antifolate, Antimycobacterial

• School: UCLA
• Department: Society and Genetics
• Course: SOC GEN 5
• Professor: Allard & Shapiro

Document Summary

Chopra & greenwood - antibacterial agents: basis of action. Prontosil - split in the bloodstream enhance a nity for bacterial cells. 1938 - federal food, drug, and cosmetic act: proof of safety of new drugs. Bacterial structure and the basis of selective toxicity. Selective toxicity: to inhibit/kill the infecting organism without harming the host. Mycobacteria - outer coat renders mycobacteria resistant to antibacterial compounds. Cytoplasmic membrane - inner membrane is not a good target for selective attack. Bacterial ribosomes - fundamental di erences in rna and ribosomes. Metabolic transformations - may not interfere directly with metabolic processes. Antibacterial agents can disrupt rna and dna synthesis. Inhibit the same targets in mycobacteria than in other bacteria. New drugs should be aimed at previously unexploited biochemical targets in the bacterial cell. Microbes which were most strongly acted on by lysozyme were those which do not infect man . Non-poisonous, but he says there is an issue with underdosage.