AH 3121 Chapter Notes - Chapter 4: Immunoglobulin D, Immunoglobulin Class Switching, Mast Cell
Document Summary
Ige functions: 2 antigen binding sites (monomer, mast cell activation (degranulation, immediate hypersensitivity, protection against parasites (worms, allergies allergic reaction = too much igg produced. Igd functions: 2 ag binding sites (monomer, na ve b cell ag receptor, no known effector functions, very little is known about igd. Used as a marker to identify na ve or mature b cell. Binding, class switching, t & b cell receptors. Antigen-antibody binding: reversible reaction, varying degrees of affinity in one complexing (ag ab binding) event. Attraction: epitope of ag is portion where ab binds, located on exposed portions of molecules. An ag must have at least 2 epitopes to bind: varying degrees of avidity in total reaction. Strength of the entire reaction: noncovalent (weaker bonds; but can be broken easily because the process is reversible) Class-switching: na ve b cells express igd and igm.
