AH 3121 Chapter Notes - Chapter 10: Mhc Class I, Cytostasis, Natural Killer Cell
Document Summary
The longer a cancer grows, expands its population and colonizes different sites and environments, the more genetic variation it acquires and the less likely the immune response can delay or terminate the disease. Strategies for immunotherapy: the main strategies for cancer immunotherapy aim to. Stimulate the patient"s own anti-tumor immune response: immunotherapy can eliminate tumors without harming the patient. Host cells incubated with tumor antigens: dna or transfected dendritic cells. Dendritic cells containing recombinant plasmids: tumor cells expressing co-stimulators or il-2. Tumor cells expressing cloned genes: cancer vaccines may boost a tumor-specific immune response. Passive cancer immunotherapy: use of monoclonal antibodies to destroy tumor cells, often linked to potent toxins, anti-her2 (erbb2) oncogene product. Her2 is overexpressed in some breast cancer cells. Anti-cd20: cd20 is expressed on normal b cells and lymphoma cells, infusion of anti-cd20. Results in reduction or cure of 50% b cell lymphomas: disadvantages. However, cd20 is not expressed by hematopoietic stem cells.
