MCB 2610 Chapter Notes - Chapter 7: Rna Polymerase Iii, Dnag, Semiconservative Replication

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Looked at virulence (disease causing capability) of streptococcus pneumoniae. Smooth s and rough r, based on colony growth. Heat killed s mixed with live r killed the mice and he was able to isolate live s bacteria. Proposed that something released from the s cells altered the phenotype of the r cells converting or transforming them from nonpathogenic r cells into pathogenic s cells transformation. Tried to figure out what was the transforming agent. Purified the transforming factor from s cells and determined that it was mostly dna but may have contained some rna and proteins. To prove it was dna they demonstrated that its ability to alter phenotype of recipient cell was not affected by proteases (enzymes that kill proteins) or rnases (enzymes that degrade rna) but the. Pathogenic strain s had a gene that results in the production of capsule and r lacks this gene. Used the bacteriophage t2 to investigate the role of dna in heredity.

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