MCB 2610 Chapter Notes - Chapter 2 & 4: Plasmid, Drug Resistance, Prokaryotic Large Ribosomal Subunit
8 Sep 2016
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Document Summary
The largest area is the nucleoid region, housing the chromosomes and dna replication machinery. A single closed circular, double-stranded dna molecule. Supercoiling produces a dense central core with loops. Nucleoid proteins (hu) probably aid in folding. Functions in protection and compaction of genomic dna. Functions in control of replication, transcription, and translation. Made up of rna, protein (pictured bottom right) 16s rrna and ssu proteins small subunit 30s. 23s rrna, 5s rrna and lsu proteins large subunit 50s. Archaea have an additional 5. 8s in large subunit (also seen in eukaryotic large subunit) Archaea more similar to eukaryal than bacteria. Episomes plasmids that can integrate into the cell chromosome. Confer selective advantage to host (like drug resistance) Functions are variable; encode non-chromosomal genes for a variety of functions. May exist in many copies in cell. Sometimes plasmids can be loss during cell division called curing. Classification of plasmids based on mode of existence, spread, and function.
