PNB 2250 Chapter Notes - Chapter 7: Carbonic Anhydrase, Myoglobin, Protein Structure
17 Sep 2016
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Respiratory proteins built with a left shift so they can get oxygen more easily into their systems. Burn oxygen at a much higher rate. Need the oxygen to come off more easily: all animals shift scale left to right. Shift thermodynamic ease by which oxygen interacts with metal; increase or decrease: hb still saturated with oxygen when they leave the lungs, lower ph, higher temp. Fish: unique adaptations, aquatic environment has much less oxygen. Slower moving left-shifted to meet metabolic needs. Faster moving right-shifted to meet metabolic needs: gills are more efficient extracting oxygen from seawater than we are at extracting oxygen from respired air, required to be an efficient extractor of oxygen. Needs to be easier-on: bigger fish burn energy slower than smaller fish, on average, fish are shifted to the left, don"t have a bohr effect because they don"t have enough carbonic anhydrase. Not enough co2 buildup in tissues to need this.
