PVS 2100 Chapter Notes - Chapter 11: Axon Hillock, Saltatory Conduction, Peripheral Nervous System

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The specific resting membrane potential of neurons depends on: (1) the electrogenic. In the receptive zone, this happens in localized regions of the cell membrane in response to the signals from other neurons in proportion to the strength of the signal, a so-called graded potential. At the junction of the axon with the cell body, the axon hillock, depolarization has a different effect, however; it is here that the action potential, a large, self-propagating wave of depolarization, is initiated. The membrane of the axon hillock and axon contains voltage-gated sodium channels; at the peak of the action potential (maximal depolarization), the sodium channels close and additional voltage-gated potassium channels are opened. The closing of the sodium channels and the exit of additional potassium repolarizes the membrane; the rapid exit of potassium produces a small afterhyperpolarization (more negative than normal resting potential) until resting conditions can be re-established.

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