ANFS140 Chapter Notes - Chapter chap 7: Glycoprotein, Chondroitin Sulfate, Aggrecan

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Overview of cartilage: cartilage is a form of connective tissue composed of cells called chondrocytes and a highly specialized extracellular matrix. Cartilage is an avascular (no blood vessels) tissue that consists of chondrocytes--cells that secrete the non-cellular matrix of cartilage and become trapped in minute spaces within it--and an extensive extracellular matrix. Chondrocytes are sparse but essential participants in producing and maintaining the matrix. The extracellular matrix is solid and firm but also somewhat pliable, which accounts for its resilience. Cartilage (especially hyaline) is a key tissue in the development of the fetal skeleton and in most growing bones. Three different types of cartilage that differ in appearance and mechanical properties are distinguished on basis of characteristics of their matrix: Hyaline cartilage is characterized by matrix containing type ii collagen fibers, gags, proteoglycans, and multiadhesive glycoproteins. Elastic cartilage is characterized by elastic fibers and elastic lamellae in addition to matrix material of hyaline cartilage.

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