CGSC170 Chapter Notes - Chapter 4.5: Functional Magnetic Resonance Imaging, Cerebral Circulation, Functional Neuroimaging
14 May 2018
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Department
Course
Professor
Local Integration II: Neural Activity and the BOLD Signal
●Interface between functional neuroimaging and the physiology of the brain
○Functional neuroimaging
■Allows us to study the workings of the brain at the level of neural systems
and large scale neural circuits
●Allows us to study the behavior of large populations of neurons
■Little is known about the relation between what those scans measure and
the cognitive activity that is going on while the measurements are being
made
■PET Technology
●Measures cerebral blood flow by tracking the movement of
radioactive water in the brain
■fMRI (Functional Magnetic Resonance imaging
●Measures levels of blood oxygenation
○Hemoglobin= oxygen carrying substance in the red blood
cells
○Deoxygenated hemoglobin disrupts magnetic fields
○Oxygenated hemoglobin does not disrupt magnetic fields
●Can track direct index of blood flow
●Indirect
■In neuroimaging, assumption that blood flow to a particular region of the
brain increases when cellular activity in that region increases
Document Summary
Local integration ii: neural activity and the bold signal. Interface between functional neuroimaging and the physiology of the brain. Allows us to study the workings of the brain at the level of neural systems and large scale neural circuits. Allows us to study the behavior of large populations of neurons. Little is known about the relation between what those scans measure and the cognitive activity that is going on while the measurements are being made. Measures cerebral blood flow by tracking the movement of radioactive water in the brain. Hemoglobin= oxygen carrying substance in the red blood cells. Oxygenated hemoglobin does not disrupt magnetic fields. Can track direct index of blood flow. In neuroimaging, assumption that blood flow to a particular region of the brain increases when cellular activity in that region increases. The degree of oxygen consumption does not increase in proportion to the increase in blood supply.
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