GEOG103 Chapter Notes - Chapter 27, 32, 35: Borrelia, Doxycycline, Amoxicillin
7 Mar 2018
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Document Summary
Syndromes and synonyms: veldt sore (cutaneous diphtheria) Agent: corynebacterium diptheriae is a gram-positive, aerobic rod that is classified into. Toxic producing strains carry a bacteriophage-derived tox gene. Human reservoirs; cattle and other livestock may harbor c. ulcerans. Transmission- respiratory droplets from people w/ respiratory diphtheria, or from asymptomatic throat or nasal carriers; direct contact w/ discharge from skin of cutaneous diphtheria cases; may carry for weeks; raw milk consumption. Respiratory diphtheria associated w/ fever, inflammation of pharynx or larynx, pseudomembrane formation, lymphadenopathy and edema of the soft tissues of the neck. Exotoxin of c. diphtheria polyneuritis and myocarditis. Nasal diphtheria mild and chronic w/ nasal discharge and ulceration. Cutaneous diphtheria chronic, sharply demarcated ulcers w/ adherent gray pseudomembrane. Isolation by culture and toxigenicity testing of strainsin labs. Therapy- neutralize potent exotoxin, eradicate organism, provide supportive care. 3 doses in first 4 months of life. Epidemiology in early 20th century diphtheria was leading cause of death in children 4-10 years in.
