PSYC414 Chapter Notes - Chapter 6: Catechol-O-Methyl Transferase, Fluoxetine, Reserpine
5 Mar 2018
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The level of serotonergic transmission depends on relative contributions of synthesis, release, and inactivation of the nt. Moclobemide- slows rate of serotonin metabolism by inhibiting monoamine oxidase a. Combination of serotonoergic agents dangerous and life-threatening symptoms serotonin syndrome: behavioral consequences include depression, anxiety, obesity, impulsive aggression and violence, and even drug addiction. Synthesized from amino acid tryptophan (comes from protein in diet) Catalyzed by tryptophan hydroxylase (enzyme) converts tryptophan to 5- hydroxytryptophan (5-htp: 2. aromatic amino acid decarboxylase (aadc) acts on 5-htp 5-ht. Two forms of tryptophan hydroxylase: tph1 expressed by non-neuronal cells, including 5-ht secreting enterochromaffin cells in the gut and melatonin secreting cells in pineal gland, tph1 expressed by serotonergic neurons. Conversion of tryptophan to 5-htp (first step) is the rate-limiting step. Aadc is the same for both catecholamine and 5-ht synthesis. Dietary effects in humans: high carb, low protein increase ratio of tryptophan to large neutral amino acids; ratio decreased with high protein low carb, little effect.
