BSC 2010 Chapter Notes - Chapter 16: X-Ray Crystallography, Frederick Griffith, Dna Replication
Document Summary
The beginnings: t. h. morgan"s group showed that genes are located on chromosomes. Two components of chromosomes dna and protein: role of dna in heredity was first discovered by studying bacteria and the viruses that infect them. The discovery of the genetic role of dna began with research by frederick griffith in 1928. Griffin & transformation: griffin looked at bacteria & mice, major finding = transformation, killed disease-causing bacteria + live, harmless bacteria. Result: live, disease-causing bacteria: transformation change in genotype and phenotype due to uptake of foreign dna. Hershey & chase: bacteriophages viruses than infect bacteria. Chargaff"s rules: in dna: [a] = [t] & [g] = [c] Structural model of dna: m. wilkins & r. franklin use x-ray crystallography to study molecular structure, watson & crick deduced that dna was 2-stranded. Dna replication: dna dna, 2 strands separate, and each one is paired using complementary bases.