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Chapter Chapter 4

PSB 3002 Chapter Notes - Chapter Chapter 4: Sublingual Administration, Intramuscular Injection, Anandamide


Department
Psychobiology
Course Code
PSB 3002
Professor
Bethany Stennett
Chapter
Chapter 4

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Chapter 4
a.Psychopharmacology-Principles of Psychopharmacology
Psychopharmacology: the study of the effects of drugs on the nervous system and
behavior
Drugs: exogenous chemicals not necessary for normal cellular functioning that
significantly alter the functions of certain cells of the body when taken in relatively low
doses
Drugs have effects and sites of action
Pharmacokinetics: what happens to the drug as it’s asored ito the ody ad reahes
its sites of action
Drugs may be administered: intravenous, intraperitoneal, intramuscular, subcutaneous,
orally, sublingually, intrarectally, by inhalation, or topically.
If the drug is lipid-soluble, they easily pass the blood-brain barrier
How do drugs exit the body? They are deactivated by enzymes or excreted.
Dose-response curve: a drug’s effetiveess. The aout adiistered vs. the resultig
effect. Drugs vary in effectiveness because the differences in their sites of actions and
the affinity between the drug and their sites of action.
Tolerance: when repeated administration of a drug results in decreased affinity of a
drug with its receptors or decreased receptors
Repeated administration of a drug can also cause withdrawal symptoms or sensitization
b.Psychopharmacology-Sites of Drug Action
Synaptic transmission
o Synthesis of neurotransmitterstorage into synaptic vesiclesrelease into
synaptic cleftinteraction with postsynaptic receptorsopening of ion channels
in the postsynaptic membraneneurotransmitter terminated by reuptake into
the terminal button/enzymatic deactivation
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