BIOS 350 Chapter 14: Syphilis History

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28 Sep 2016
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Oslo study-> 2000 norwegian patients in 20 years, assessed for outcome in late 1940s-early. Tuskegee-> 431 black men followed for 30 years, higher post-mortem rate achieved than in. Primary syphilis: chancre develops 10-90 days, systemic dissemination of spirochetes. Secondary syphilis: clinically apparent 60-90% of time, 4-10 weeks following chancre, recurrence possible. Early latent syphilis: less than 1 year duration. Late latent syphilis: greater than one year s duration. Gummatous disease: 15% develop chronic inflammatory lesions in skin, bone, and multiple organ sites. 10% develop oslo, higher incidence in autopsied patients. Meningitis: first 2 years following infection, aseptic meningitis, febrile cranial nerve findings. Meningovascular: 5-10 years, secondary to cns arteries and stroke. Tabes dorsalis: general paresis- greater than 10 years after acquisition. Wwi: estimate 6% in us had syphilis , prevalence as high as 50% in some european cities. 1930s: parran(10% in us with syphilis), as high as 25- Salvarsan, arsenicals: effective against 1-3, not against neurosyphilis.

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